Currently, Spidey is just a newbie. If he were facing Dr. Connors, who had never fought before and relied solely on instinct, the two would be evenly matched, exchanging blows back and forth.

However, due to a slight butterfly effect, the person transformed into the Lizardman is not Dr. Connors, but some unknown guy.

And he's an elite from the military. If Spidey had defeated the Green Goblin or Doctor Octopus before, he might have been able to take down this Lizardman. Unfortunately, Spidey is still just a rookie.

Soon, under the relentless assault of the Lizardman, Spidey found himself at a disadvantage. If Natasha continued to sit idly by, Spidey would be torn apart by the Lizardman.